Open mitochondrial research · Plain-language explainer

Published on Zenodo · September 11, 2026

Initial Construct Validation of the Mito Map Energy Score Against a Composite Functional Measure

Friedl, Andrew

Abstract

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0.907; 95% CI 0.781 to 0.962), with supporting rank-correlation, leave-one-out, objective-only, protocol, and agreement analyses. These findings support initial convergent construct validity but do not establish diagnostic validity, clinical utility, or prospective prediction.

DOI: 10.5281/zenodo.22713520

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The paper at a glance

The question

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0. 907; 95% CI 0.

Main takeaway

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0. 907; 95% CI 0. 781 to 0.

Important caution

This is a research synthesis, not clinical guidance. The paper describes uncertainty and limits in the underlying evidence.

Why this matters

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0. 907; 95% CI 0.

How the research was done

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0. 907; 95% CI 0.

What the researchers found

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. The Energy Score was strongly associated with the Measured Function Score (Pearson r = 0. 907; 95% CI 0. 781 to 0.

What this does not prove

This is a research synthesis, not clinical guidance. The paper describes uncertainty and limits in the underlying evidence.

What researchers should test next

Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants.

For non-specialists

What this could mean for patients and families

This research helps organize how scientists think about initial construct validation of the mito map energy score against a composite functional measure. Initial internal construct validation of the Mito Map Energy Score against a separately recorded composite of grip strength, five-times sit-to-stand performance, baseline fatigue, and post-task fatigue. The primary pipeline-defined analysis included 21 participants. It does not establish a diagnosis, prove that a treatment works, or tell an individual person what care to pursue.

  • What was directly measured, and what was inferred?
  • Were the findings in people, animals, cells, or a mixture?
  • What result would disprove or narrow the proposed explanation?
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