Chief Executive Officer
Andrew Friedl, MS, MBA
Systems engineering, data science, modeling, and lived experience with a TWNK mutation.
Cancer care × performance status
Cancer care tracks the tumor. What tracks the patient’s actual performance?
Mito Map connects patient-reported energy, daily function, treatment context, and recovery on one longitudinal timeline.
A need for better methods to track mitochondrial function.
For cancer centers, survivorship programs, investigators, foundations, and patient organizations.
Patient energy signalVisible between visits
Longitudinal
BaselineMid-treatmentPost-treatmentRecovery
Patient reportEnergy + fatigue
Daily functionWhat life allows
ContextTreatment + recovery
Illustrative trajectory—not patient data or a clinical prediction.
What the science supports today
A coherent signal—promising, but not yet causal.
Clinical studies have connected cancer-related fatigue or functional impairment with mitochondrial respiration, gene expression, mitochondrial DNA measures, skeletal-muscle oxidative capacity, and at-home digital measures of activity and gait. The literature supports measurement and further study; it does not establish mitochondria as the single cause of cancer-related fatigue.
New · At-home monitoring · multiple cancer typesImproved functional assessment in cancer patients using home-based digital technologies
Wearable activity and gait measures reflected performance status, physical function, and fatigue.
Karahanoglu et al., 2025 ↗ Radiation therapy · prostate cancerFatigue increased as Complex III-linked mitochondrial respiration decreased.Hsiao et al., 2018 ↗ Combined ADT + radiotherapy · prostate cancerPatient fatigue was studied alongside mitochondrial oxygen consumption.Feng et al., 2020 ↗ Survivorship · breast cancerWhole-blood mitochondrial gene expression was examined in relation to persistent fatigue.Kleckner et al., 2022 ↗ Post-treatment · multiple cancer typesMuscle oxidative capacity was paired with objective function and patient-reported outcomes.Gonsalves et al., 2024 ↗Cancer-related fatigue is multifactorial. Energy tracking should complement—not replace—clinical evaluation for anemia, pain, sleep disruption, mood, nutrition, medication effects, disease activity, and other contributors. Read the National Cancer Institute overview ↗ Several influential prostate-radiotherapy studies come from the same research program and may include related cohorts. Independent replication, larger samples, and broader cancer populations are still needed.
Company overview
A patient-centered measurement company built around change over time.
Mito Map organizes symptoms, function, treatments, labs, recovery, and lived context into a longitudinal record. The cancer energy program extends that platform toward a focused question: can we make declining or recovering capacity visible early enough to support better research and better conversations?
Meet Mito MapLongitudinal by designBuilt to follow within-person change, not only one-time snapshots.
Patient + objective signalsDesigned to connect lived energy with repeatable measures of function.
Research-ready directionStructured around cohorts, trajectories, provenance, and transparent limitations.
Leadership
Built across patient experience, medicine, engineering, and operations.
Chief Operating Officer
Kyle Radcliffe, MBA
Nuclear engineering, technology operations, organizational scale, and disability advocacy.
Chief Medical Officer
Deborah Manst, MD, MPH
Preventive medicine, public health, cancer survivorship, and mitochondrial disease experience.
Director of Business Development
Paul Manst
Cancer partnerships, business development, and external collaboration.
Scientific advisory network in formation.We are seeking oncology, survivorship, cancer rehabilitation, mitochondrial biology, digital-measurement, and biostatistics advisors. No external advisor or institutional endorsement is implied until a relationship is confirmed.
Partner network
A collaboration model for building the missing signal.
Mito Map is developing the cancer energy program as a partnership surface. Each organization can contribute a different part of the evidence pathway.
Cancer centers and survivorship programs
Define cohorts, workflows, clinical context, and the questions that matter at the point of care.
Investigators and laboratories
Connect longitudinal function with mitochondrial biology, treatment exposures, and rigorous analysis.
Foundations and patient organizations
Shape meaningful outcomes, equitable recruitment, communication, and participant value.
Wearables and digital measurement
Add home-based activity, gait, sleep, and recovery signals that clinic snapshots can miss.
These are proposed collaboration roles, not a claim that organizations in these categories currently endorse or partner with Mito Map.
Research roadmap
Studies designed to move from feasibility to validation.
Cancer Energy Feasibility Pilot
Test participation burden, completion, trajectory quality, and the relationship among patient energy, function, treatment timing, and optional wearable measures.
- Design
- Prospective longitudinal pilot
- PI / site
- Seeking oncology collaborator
Mito Map Correlation Trial
A proposed remote study testing whether model-derived energy and home-measured function move together within the same person over time.
- Design
- Remote longitudinal validation
- PI / site
- To be confirmed
Cancer Energy Investigator Group
Bring oncology, rehabilitation, mitochondrial biology, digital measurement, and patient leadership together around shared endpoints and study design.
- Near-term output
- Advisory review + pilot protocol
- Leadership
- Mito Map + collaborating investigators
Build the evidence with us
Bring one cohort, one question, or one piece of the measurement stack.
We’ll shape a low-burden first collaboration around your population, expertise, and research goals.
Partner with Mito Map